Supplementary file 1_A novel age-norm–capped baseline serum creatinine approach for acute kidney injury diagnosis in critically Ill children: a retrospective cohort study.docx

We aimed to evaluate a novel approach for defining baseline SCr by comparing its implications for AKI classification and prognosis with those of admission SCr.</p>Methods<p>This retrospective study utilized data from the Paediatric Intensive Care (PIC) database.

We compared two distinct baseline SCr definitions: 1) the “Admission SCr” and 2) a novel “Norms-Capped SCr”, defined as the admission SCr if it was less than or equal to the age-specific normal maximum (NormsMax), or the NormsMax value if the admission SCr exceeded it. Both baseline definitions were then used to classify AKI according to three different diagnostic criteria. We subsequently compared the resulting AKI incidence, stage distribution, and prognostic performance for clinical outcomes across these different baseline-criterion combinations.</p>Results<p>A total of 3,021 critically ill children were included.