Omics · study · 2026
RNA-seq analysis of FDX2-inducible knockout (FDX2-iKO) ES2 ovarian carcinoma cells under normoxic and hypoxic conditions
Listed in NCBI GEO
This dataset provides RNA-seq profiles of human ES2 ovarian carcinoma cells harboring a doxycycline-regulated, inducible knockout of the FDX2 gene (FDX2-iKO ES2 cells).
Description
In this Tet-off system, FDX2 expression is maintained in the presence of doxycycline, while FDX2 knockout is induced upon doxycycline withdrawal. Cells were cultured under normoxic (20% O₂) or hypoxic (3% O₂) conditions, with or without doxycycline.
The aim of this study was to define the transcriptional consequences of FDX2 loss under varying oxygen levels. Raw read counts and processed data are provided to facilitate comparative expression analyses.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324929 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324929 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1438110 ncbi.nlm.nih.gov/bioproject/PRJNA1438110 ↗
project · from NCBI GEO
- PubMed 42208897 pubmed.ncbi.nlm.nih.gov/42208897 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE324929 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |