Supplementary file 1_Near-final adult height after GnRHa plus growth hormone in central precocious puberty: a single-center cohort study and predicted adult height validation audit.docx

Height gain and change in height standard deviation score (SDS) from baseline to 24 months were secondary outcomes. Results: Mean NFAH was 160.17 cm with GnRHa alone and 161.87 cm with GnRHa + rhGH. The adjusted M2 association was +2.26 cm (95% CI 0.12 to 4.40); the chart-PAH-conditioned M3 estimate was +0.58 cm (−1.60 to 2.75) and was treated as diagnostic.

At 24 months, M2 estimates were +3.23 cm (2.00 to 4.46) for height gain, +3.24 cm (2.03 to 4.46) in analysis of covariance (ANCOVA) of attained height, and +0.46 SDS (0.27 to 0.66). In the criterion-confirmed female bone-age cohort, M2 estimates were +0.00 years (−0.27 to 0.27) for bone age at 24 months and −0.14 years (−0.30 to 0.03) for bone-age progression.</p>Conclusions<p>Adjunctive rhGH was associated with greater growth over 24 months and a positive, imprecisely estimated NFAH difference.

Because this was an observational study, ascertainment criteria were heterogeneous, and the NFAH estimate was sensitive to PAH adjustment and criterion restriction, the adult-height finding should be interpreted cautiously.</p>