Omics · study · 2026
ST2 Signaling Regulates Innate Immune Response in Kidney Injury
Listed in NCBI GEO
IL-33/ST2 signaling plays a crucial role in macrophage function during kidney injury.
Description
Using myeloid cell-specific ST2 knockout mice, the study revealed that ST2 deficiency attenuates renal damage in acute IRI but exacerbates it in chronic IRI. RNAseq and functional assays showed that ST2 is critical for macrophage-mediated efferocytosis and mitochondrial metabolism.
The findings highlight the importance of IL-33/ST2 signaling in regulating macrophage activity and maintaining tissue homeostasis during renal injury.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE288nnn/GSE288154 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE288154 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1216286 ncbi.nlm.nih.gov/bioproject/PRJNA1216286 ↗
project · from NCBI GEO
- PubMed 41659640 pubmed.ncbi.nlm.nih.gov/41659640 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE288154 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |