Omics · study · 2026
Investigation of androgen receptor signaling in aged and Alzheimer's disease brains
Listed in NCBI GEO
Androgen signaling via the androgen receptor (AR), a ligand-dependent transcription factor within the steroid receptor superfamily, plays a vital role in the development and regulation of neuronal activity.
Description
Despite this, the mechanisms by which AR signaling is sustained or altered in human brain tissues remain unexplored. To deepen our understanding of AR function in the human brain, we conducted ChIP-seq (chromatin immunoprecipitation followed by sequencing) to identify AR and its associated transcription factors binding sites, and histone-acetylated regions in brain tissues from elderly individuals and patients with Alzheimer's disease (AD).
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE295nnn/GSE295402 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE295402 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1254595 ncbi.nlm.nih.gov/bioproject/PRJNA1254595 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE295402 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |