Omics · study · 2026
Lactate Drives Epigenetic Reprogramming and Activation of Hepatic Stellate Cells via Altering Chromatin Accessibility
Listed in NCBI GEO
Activation of hepatic stellate cells (HSCs) is a central driver of liver fibrosis, and the metabolite lactate has emerged as a potential signaling molecule beyond its role in metabolism.
Description
To investigate whether it influences HSC activation through epigenetic mechanisms, we treated human primary HSCs with L-lactate and utilized Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) to map genome-wide changes in chromatin accessibility, complemented by assays for gene expression to correlate these changes with the pro-fibrotic activation phenotype.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310086 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310086 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1365109 ncbi.nlm.nih.gov/bioproject/PRJNA1365109 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 69% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE310086 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |