Omics · study · 2026
Nobiletin targets CHEK1-H3K27ac-CENPM axis and suppresses the malignancy of colorectal cancer
Listed in NCBI GEO
Pharmacological intervention targeting super-enhancer activity represents a promising therapeutic approach to suppress the expression of oncogenes.
Description
The challenges remain in unveiling the key factors accounting for the hyperactive super-enhancers in cancers and small molecules for the functional inhibition. In this study, we identified CHEK1 as a critical factor for sustaining the high level H3K27ac enrichment in the super-enhancer regions of oncogenes.
Nobiletin was found as an inhibitor of CHEK1. We made these findings in the efforts to decipher the molecular mechanism underlying a modified Traditional Chinese Medicine formula Liujunzi Decoctiom (mLJZD). We experimentally confirmed the anti-cancer function of mLJZD both in vitro and in vivo.
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Through an interactive analysis of RNA profiling data, we identified oncogenic CENPM as a critical effector gene that is downregulated by mLJZD
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298436 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298436 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1269447 ncbi.nlm.nih.gov/bioproject/PRJNA1269447 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE298436 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |