TDP-43 regulates ferroptosis to modulate the malignant progression of lung adenocarcinoma

TAR DNA-binding protein 43 (TDP-43) is involved in multiple tumor-associated biological processes, while its functional role and underlying mechanism in LUAD progression remain to be elucidated. Ferroptosis, a form of iron-dependent regulated cell death, plays a critical role in tumor development and progression.

In this study, we investigated the regulatory effect of TDP-43 on ferroptosis and its subsequent impact on LUAD malignant progression. The expression pattern of TDP-43 in LUAD tissues and its correlation with clinical prognosis were analyzed. Functional experiments were performed to verify the effects of TDP-43 on LUAD cell proliferation, cell death and ferroptosis progression.