Omics · study · 2026
Intracranial mesenchymal tumor, FET-CREB fusion-positive: an integrative analysis of 81 cases
Listed in NCBI GEO
Intracranial mesenchymal tumors, FET-CREB fusion-positive (ICMT ) show fusions involving FET RNA-binding protein family gene (EWSR1 or FUS) and CREB family of transcription factors (ATF1, CREB1 or CREM).
Description
The methylation characteristics and clinical behavior of this important tumor type require further characterization. We study the methylation profiles of 81 ICMT cases (61 newly profiled cases and 20 cases from publicly available sources).
ICMT showed a relatively distinct methylation signature compared to related tumors. We confirmed the prior description of two distinct subgroups of ICMT (subclasses A and B).
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308071 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308071 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1328696 ncbi.nlm.nih.gov/bioproject/PRJNA1328696 ↗
project · from NCBI GEO
- PubMed 41569358 pubmed.ncbi.nlm.nih.gov/41569358 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Methylation profiling by genome tiling array · Third-party reanalysis
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE308071 | 8 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-genome-tiling-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:third-party-reanalysis | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |