Imaging · study · 2026
TRPV1–STAT3 signaling as a driver of lethal pathology during pneumococcal nose-to-brain invasion
Listed in NCBI GEO
To investigate mechanisms underlying lethal pneumococcal nose-to-brain infection, we established a murine intranasal Streptococcus pneumoniae infection model with methimazole-induced olfactory epithelial injury and/or resiniferatoxin-mediated trigeminal TRPV1 ablation.
Description
Spatial transcriptomic analysis identified a distinct inflammatory transcriptional cluster localized to the olfactory epithelium and adjacent olfactory bulb in methimazole-treated mice.
The cluster showed enrichment of STAT3-associated transcriptional programs and inflammatory pathways. These findings suggest that olfactory epithelial injury and trigeminal TRPV1 signaling contribute to localized inflammatory responses during pneumococcal nose-to-brain invasion.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE331nnn/GSE331225 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331225 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1467531 ncbi.nlm.nih.gov/bioproject/PRJNA1467531 ↗
project · from NCBI GEO
Topics
- Stated by source
- Mus musculus · Other
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE331225 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |