Omics · study · 2026
Local brain reprogramming mitigates Alzheimer's disease and associated bone loss
Listed in NCBI GEO
Alzheimer's disease (AD) is a debilitating neurodegenerative disorder marked by glia cell inflammation, neuron loss, cognitive impairment, and systemic dysfunctions, including bone loss.
Description
The progression of AD is accompanied by aging and epigenetic alterations that disrupt cellular homeostasis. Here, we demonstrate that a coexpression vector (AAV-OSK) containing Oct4, Sox2, and Klf4 preserves microglial and neuronal cells identities, while reducing neuroinflammation and neuronal apoptosis.
Localized brain treatment with AAV-OSK enhances cognitive function, neuronal health, Aβ plaque clearance, microglial activity, and myelin integrity in early- and late-stage AD mouse models. Reduced representation bisulfite sequencing (RRBS) analysis indicated that these therapeutic benefits require DNA demethylation during reprogramming. Furthermore, this brain reprogramming approach also improves osteogenesis in AD-affected bone tissue.
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These findings suggest that reprogramming brain tissue can unlock youthful epigenetic information through DNA demethylation offering a novel strategy to improve both brain and extracerebral organ health in AD individuals.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE288nnn/GSE288182 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE288182 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1216536 ncbi.nlm.nih.gov/bioproject/PRJNA1216536 ↗
project · from NCBI GEO
- PubMed 42210397 pubmed.ncbi.nlm.nih.gov/42210397 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Methylation profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE288182 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |