Omics · study · 2026
Impaired taurine transport contributes to the development of bronchopulmonary dysplasia
Listed in NCBI GEO
Sprague-Dawley rat pups were used to study the effect of taurine supplementation on hyperoxia-exposed lungs.
Description
The study, which was conducted with meticulous attention to detail, found significant effects of taurine supplementation. Rat pups were randomly assigned to room air (NOX) and >90% oxygen (HOX) from postnatal day 1 (P1) to P10.
Half of the pups of each group received a daily taurine (100 mg/kg) intraperitoneal injection or an equal volume of PBS (two by two design). The four groups were NOX-PBS, NOX-taurine, HOX-PBS, and HOX-taurine. At P10, a comprehensive range of methodologies was employed, including morphometrics, histology, metabolomics, and immunoblots.
Read the rest (1 more)
Two pups, one male and one female, were randomly selected for single-cell RNA sequencing at P10
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294892 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294892 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1251979 ncbi.nlm.nih.gov/bioproject/PRJNA1251979 ↗
project · from NCBI GEO
- PubMed 41738245 pubmed.ncbi.nlm.nih.gov/41738245 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE294892 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |