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Omics · study · 2026

Intracellular complement factor H protects neurons during CNS inflammation [bulkRNA-seq]

Listed in NCBI GEO

Complement factor H (CFH) has been implicated in neuroprotection during inflammatory neurodegeneration, but its neuron-intrinsic functions remain poorly understood.

Description

Here, we performed bulk RNA sequencing of primary neuronal cultures from Cfh conditional knockout (Cfh-cKO) and control mice under basal conditions or following glutamate-induced oxidative stress. This dataset was generated to characterize transcriptional changes associated with neuronal Cfh deficiency and to identify pathways regulated by intracellular CFH during neuronal stress responses.

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From keywords
Life Sciences
Inferred from text
RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE33275913 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:sequencingenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[organism].NCBITaxon:10090source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title