Omics · study · 2026
POFUT1 Serves as an Independent Prognostic Factor and Therapeutic Target by Activating the PI3K/AKT Pathway in Glioma
Listed in NCBI GEO
Protein O - Fucosyltransferase 1 (POFUT1) is a significantly different gene in gliomas.
Description
The analysis of the The Cancer Genome Atlas Program (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases and clinical samples found that POFUT1 was highly expressed in tumor tissue (p < 0.01). Glioma patients with high POFUT1 had a significantly poorer clinical prognosis than those with low POFUT1.
And POFUT1 amplification and protein overexpression were significantly correlated with malignant progression and poor prognosis in glioma patients. Furthermore, our experimental results found that knocking down POFUT1 can inhibit the abilities of proliferation and migration in gliomas. RNA sequencing was found that the downstream significantly differentially expressed genes of POFUT1 are enriched in the PI3K-AKT signaling pathway, and cell experiments also verified this result.
Read the rest (1 more)
Our results suggest that POFUT1 may affect the malignant progression of glioma by regulating the PI3K-AKT signaling pathway. The result may provide new insights into the treatment of glioma.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316535 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316535 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1403273 ncbi.nlm.nih.gov/bioproject/PRJNA1403273 ↗
project · from NCBI GEO
- PubMed 42675310 pubmed.ncbi.nlm.nih.gov/42675310 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE316535 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |