Gene expression profiling of hindpaw tissues in a spontaneous arthritis mouse model to explore pathological ossification and the effects of non-pharmacological interventions

The spontaneous arthritis (SpAD) mouse model reproduces key features of human axial spondyloarthritis, including abnormal joint ossification. This dataset captures transcriptional profiles from joint-associated tissues under various non-pharmacological interventions, such as exercise and intermittent fasting, providing insights into mechanisms of inflammation and ectopic ossification.

Gene expression profiling was conducted on distal hindpaw tissues from DBA/1 mice with spontaneous arthritis using GeneChip Clariomª D microarrays. Mice were assigned to groups with or without interventions including treadmill exercise and intermittent fasting. Healthy BALB/c mice were included as controls.