Excel · study · 2026
Magnesium isoglycyrrhizinate alleviates alcohol- associated liver disease through targeting HSD11B1
Listed in NCBI GEO
Objective: To assess gene expression differences in liver tissues of National Institute on Alcohol Abuse and Alcoholism (NIAAA) mouse models induced by alcohol-containing liquid diets, with or without magnesium isoglycyrrhizinate (MgIG) treatment.
Description
Methods
The NIAAA mouse model was established through dietary intervention and divided into three groups: control + saline (n=3), NIAAA + saline (n=3), and NIAAA + MgIG (n=3). After 16 days of modeling, mice were sacrificed, and liver tissues were collected for RNA sequencing analysis. Comparative analysis of gene expression among the three groups was conducted to identify potential therapeutic targets of MgIG.Results: The findings suggest that genes such as Idi1, Acot2, Gstm1, and Ugt1a5 may play a role in mediating the protective effects of MgIG in the NIAAA model.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE284nnn/GSE284311 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284311 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1198510 ncbi.nlm.nih.gov/bioproject/PRJNA1198510 ↗
project · from NCBI GEO
- PubMed 42517344 pubmed.ncbi.nlm.nih.gov/42517344 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE284311 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |