Excel · study · 2026
Diabetes-Induced Hearing Loss via Next-Generation Sequencing Research Model
Listed in NCBI GEO
Emerging evidence implicates the cochlea as a potential site of injury, yet the underlying molecular mechanisms remain poorly defined.
Description
In this study, we employed a streptozotocin (STZ)-induced type 1 diabetic mouse model to investigate cochlear dysfunction and region-specific transcriptomic alterations. Auditory brainstem response testing revealed significant hearing threshold elevation and reduced outer hair cell function in diabetic mice.
RNA sequencing of microdissected cochlear regions including modiolus, lateral wall, and organ of corti, identified hundreds of differentially expressed genes per region, with the lateral wall exhibiting the most extensive transcriptional changes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303895 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303895 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1298182 ncbi.nlm.nih.gov/bioproject/PRJNA1298182 ↗
project · from NCBI GEO
- PubMed 42510876 pubmed.ncbi.nlm.nih.gov/42510876 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE303895 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |