Omics · study · 2026
Characterizing the tumor microenvironment at the single-cell level reveals the potential immune evasion mechanism in giant cell tumor of bone
Listed in NCBI GEO
Giant cell tumor of bone (GCTB) is intermediate, locally aggressive primary bone tumor that are usually occur in long bones and typically present as lytic lesions, leading to cortical expansion or destruction with a soft-tissue component.
Description
At present, the main treatment of GCTB is surgical curettage and bone cement filling, but the recurrence rate is more than 20%. It is known that tumor recurrence and immune escape are closely related to the microenvironment.
We need a deeper understanding of the complex tumor microenvironment, as well as the role of various immune cells in the development of GCTB, in order to achieve a comprehensive treatment of GCTB.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE341nnn/GSE341436 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE341436 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1502762 ncbi.nlm.nih.gov/bioproject/PRJNA1502762 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE341436 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |