Excel · study · 2026
Association between environmental contaminant TBOEP and hepatic metabolism
Listed in NCBI GEO
tris(2-butoxyethyl) phosphate (TBOEP) is a common organophosphorus compound widely used in industrial production as a plasticizer and flame retardant.
Description
In recent years, studies have shown that TBOEP may pose potential threats to human health, particularly its association with liver metabolic function has attracted widespread attention. The liver, as the most important metabolic organ in the human body, plays a crucial role in detoxification, synthesis, and decomposition of various biomolecules.
After entering the human body, TBOEP is mainly metabolized and detoxified by the liver. However, TBOEP and its metabolites may interfere with the normal function of the liver, leading to metabolic disorders. Research has shown that TBOEP exposure may affect the activity of enzymes in the liver, such as the cytochrome P450 enzyme system, which plays an important role in drug metabolism and endogenous substance synthesis.
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Long-term exposure to TBOEP may also lead to liver inflammation and fatty degeneration, further affecting liver metabolic function. In addition, TBOEP may also affect liver metabolic pathways by influencing gene expression. For example, TBOEP exposure may activate or inhibit genes related to lipid metabolism, glucose metabolism, and oxidative stress, thereby altering the metabolic state of the liver.
These changes not only affect the function of the liver itself but may also have a chain reaction on the health of other organs and systems through the interaction of the systemic metabolic network. In summary, as an environmental pollutant, the potential impact of TBOEP on liver metabolic function cannot be ignored. Future research needs to further explore the toxicological mechanisms of TBOEP and its long-term effects on human health in order to develop effective prevention and intervention measures to protect public health.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299130 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299130 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1272627 ncbi.nlm.nih.gov/bioproject/PRJNA1272627 ↗
project · from NCBI GEO
- PubMed 41775458 pubmed.ncbi.nlm.nih.gov/41775458 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE299130 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |