Omics · study · 2026
Transcriptomic and epigenomic analysis of WSTF knockdown in colorectal cancer cells [ChIP-Seq]
Listed in NCBI GEO
This study investigates the role of Williams syndrome transcription factor (WSTF/BAZ1B) in colorectal cancer (CRC) progression through multi-omics approaches.
Description
WSTF was knocked down in SW620 colorectal cancer cells using siRNA to assess its impact on gene expression and metabolism. Additionally, WSTF overexpression was performed followed by ChIP-seq to identify genome-wide binding sites and direct transcriptional targets.
The study aims to elucidate WSTF-mediated regulatory mechanisms and identify potential downstream effectors including GLYCTK in CRC.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328335 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328335 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1454275 ncbi.nlm.nih.gov/bioproject/PRJNA1454275 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE328335 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |