Data · study · 2026
Transcriptional changes in Drosophila tbph mutants and inducible neuronal TBPH rescue in adult heads at 60 hours post-eclosion
Listed in NCBI GEO
TBPH, the Drosophila ortholog of human TDP-43, is required for normal neuronal function.
Description
To identify transcriptional programs altered by loss of TBPH and those restored by neuronal re-expression of TBPH, we performed Affymetrix microarray profiling on adult heads from wild-type (w1118) animals, two independent tbph loss-of-function mutants (tbph^Δ23 and tbph^Δ142), and a tbph mutant line carrying an elav-GeneSwitch-driven UAS-TBPH transgene activated by feeding 5 mM RU-486 for 60 hours post-eclosion (Rescue).
Comparison of mutants vs control identified a shared dysregulated transcriptional signature; comparison of rescue vs mutants identified the subset of these genes whose expression was restored by inducible neuronal TBPH re-expression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330574 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330574 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1464636 ncbi.nlm.nih.gov/bioproject/PRJNA1464636 ↗
project · from NCBI GEO
- PubMed 42353079 pubmed.ncbi.nlm.nih.gov/42353079 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Drosophila melanogaster · Expression profiling by array
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE330574 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:7227 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |