Omics · study · 2026
Analysis of the mechanism of acquisition of chemotherapy resistance in colorectal cancer cell lines
Listed in NCBI GEO
Although anticancer drugs such as fluorouracil and oxaliplatin are widely used in the treatment of colorectal cancer, they are ineffective when cancer cells acquire drug resistance.
Description
The treatment strategy for colorectal cancer that has acquired drug resistance has become a problem in chemotherapy. To investigate the cause of drug resistance, we created drug-resistant strains of colon cancer cell lines by mixing a small amount of anticancer drug in the culture medium and culturing them for a long period of time, and explored the genetic changes by RNA-sequence.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE289nnn/GSE289766 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE289766 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1224754 ncbi.nlm.nih.gov/bioproject/PRJNA1224754 ↗
project · from NCBI GEO
- PubMed 42120524 pubmed.ncbi.nlm.nih.gov/42120524 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE289766 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |