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Omics · study · 2026

Transcriptome profiling of PAXX knockdown in HCT116 colorectal cancer cells

Listed in NCBI GEO

To investigate the transcriptional changes induced by PAXX depletion in colorectal cancer cells, bulk RNA sequencing was performed in HCT116 cells transfected with PAXX-targeting siRNA or negative-control siRNA.

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Three independent biological replicates were analyzed for each group.

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Expression profiling by high throughput sequencing · Homo sapiens
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Life Sciences
Inferred from text
Bioinformatics and computational biology 68% · Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 11 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE34688714 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[disease].local:disease:cancerenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[field].anzsrc:group:3102enrichment · NCBI GEOtaxonomy-embedding@1.1.0title+keywords+description (68%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:sequencingenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[organism].NCBITaxon:9606source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title