Omics · study · 2026
Single cell transcriptome analysis of human primary osteoblasts
Listed in NCBI GEO
This study collected three femoral head samples, optimized the experimental workflow for osteoblast isolation and conducted single-cell transcriptomic sequencing.
Description
During the bioinformatic analysis of the single-cell transcriptomic data, we annotated into 10 cell types: OB, NE, Chondrocytes (CHON), Erythrocytes (ER), Macrophages (MAC), B cells (B), T cells (T), plasma cells (PC), Endothelial cells (EC), Smooth muscle cells (SMC).
Using CellChat, we identified distinct ligand and receptor expression patterns across various cell types. These analyses allowed us to identify unique signaling mechanisms for each cell population and uncover functional communication among different cell types.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE286nnn/GSE286109 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE286109 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1207949 ncbi.nlm.nih.gov/bioproject/PRJNA1207949 ↗
project · from NCBI GEO
- PubMed 41993107 pubmed.ncbi.nlm.nih.gov/41993107 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Bioinformatics and computational biology 72% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE286109 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3102 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (72%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |