Excel · study · 2026
Tumor-Associated Senescent Non-Classical Monocytes Promote Immune Suppression and Progression of Advanced Prostate Cancer [CUT&Run]
Listed in NCBI GEO
Prostate cancer, a leading cause of male cancer mortality, poses major therapeutic hurdles due to its immunosuppressive tumor microenvironment (TME).
Description
We link MYC amplification and PTEN deletion to metastatic prostate adenocarcinoma and identify a specific population of tumor-associated non-classical monocytes (staNC-Mo, CD11b+Ly6cLowCD14HiCD43LowCX3CR1Low) as key mediators of immune suppression. MYC overexpression with Pten loss induces mitochondrial stress, triggering tumor-cell apoptosis and HSP60 release.
The HSP60/TLR4 signaling activates staNC-Mo to secrete TNF-α, stimulating endothelial G-CSF production and driving staNC-Mo differentiation in bone marrow and spleen. CD14-dependent phagocytosis of apoptotic tumor cells drives staNC-Mo senescence and TGF-β1 secretion. TGF-β1 activates PI3K/AKT signaling in tumor cells, inducing CXCL5 secretion and reinforcing staNC-Mo recrutiment.
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Senescent staNC-Mo also release IL-18, suppressing innate and adaptive immunity. Targeting Ly6c, CD14, CXCL5-CXCR2, TLR4, or IL-18 reduces staNC-Mo accumulation, relieves TME immunosuppression, and inhibits tumor progression, suggesting therapeutic strategies for advanced prostate cancer.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345439 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345439 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1520410 ncbi.nlm.nih.gov/bioproject/PRJNA1520410 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE345439 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |