Omics · study · 2026
Gene expression profiing of C28/I2 Human Chondrocyte Cell Line with control and FGF9 shRNA
Listed in NCBI GEO
Osteoarthritis (OA) is an age-related degenerative joint disease.
Description
Ccartilage gradually degraded underlying joint bones during OA development. Gene expression profiling analysis was conducted on human OA primary chondrocytes and their normal counterparts.
We identified the downregulation of FGF9 in OA primary chondrocytes compared to normal counterparts. Depletion of FGF9 expression by specific FGF9 shRNA in chondrocytes significantly exacerbates senescence and ROS level.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE276nnn/GSE276762 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE276762 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1158821 ncbi.nlm.nih.gov/bioproject/PRJNA1158821 ↗
project · from NCBI GEO
- PubMed 42234537 pubmed.ncbi.nlm.nih.gov/42234537 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE276762 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (68%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |