Omics · study · 2026
Butyrate is anti-inflammatory at low and pro-inflammatory at high concentrations
Listed in NCBI GEO
Butyrate is a four-carbon short-chain fatty acid produced from microbial fermentation of dietary fibers present at high millimolar concentrations in the colonic lumen.However, in an intact epithelium, macrophages residing in the lamina propria areexposed to only sub-millimolar butyrate concentrations.
Description
Current studies show antiinflammatoryproperties of butyrate and suggest that it might have therapeuticapplications in inflammatory bowel disease and colonic cancer.
We now show that theeffect of butyrate on human macrophages is strongly concentration dependent. At lowconcentrations (0.1–1 mM), butyrate suppresses LPS-induced production ofproinflammatory cytokines potentially through a combination PPAR-γ signaling andincreased histone acetylation. At high concentrations (10 mM), butyrate promotesproduction of inflammatory cytokines in a mechanism that involves G protein-coupledreceptor GPR109A, the lipid transporter CD36, and the kinase SRC.
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We propose thatbutyrate is a crucial signaling molecule for intestinal integrity, since intestinaldisruption exposes macrophages to high butyrate concentrations.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE272nnn/GSE272870 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE272870 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1139156 ncbi.nlm.nih.gov/bioproject/PRJNA1139156 ↗
project · from NCBI GEO
- PubMed 40381959 pubmed.ncbi.nlm.nih.gov/40381959 ↗
publication · from NCBI GEO
- PubMed 42491727 pubmed.ncbi.nlm.nih.gov/42491727 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE272870 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |