Omics · study · 2026
Transcriptomic profiling of BAZ1A-AS1 and BAZ1A knockdown in human vascular smooth muscle cells and rhabdomyoblasts
Listed in NCBI GEO
BAZ1A-AS1 is a novel human-specific long non-coding RNA upregulated during neointima proliferation in human saphenous veins.
Description
To elucidate the transcriptional programs regulated by BAZ1A-AS1 and its cis-regulatory gene BAZ1A, we performed bulk RNA-seq on human saphenous vein smooth muscle cells (HSVSMCs) with BAZ1A-AS1 knockdown (LNA gapmeR ASO) and rhabdomyoblast (RD) cells with BAZ1A knockdown (siRNA) under UV exposure.
Differential expression analysis revealed convergent suppression of proliferative, inflammatory, and stress-response transcriptional programs across both knockdowns, supporting a shared regulatory axis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329766 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329766 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1461705 ncbi.nlm.nih.gov/bioproject/PRJNA1461705 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE329766 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |