Omics · study · 2026
DNA Copy Number Analysis of Germ Cell Tumors in the Thai Population
Listed in NCBI GEO
This project aims to identify CNVs of intracranial and extracranial germ cell tumors in the Thai population.
Description
Formalin-fixed paraffin-embedded tissues (FFPET) from intracranial (IGCTs) and extracranial germ cell tumors (EGCTs) were extracted and analyzed using SNP microarray, and somatic CNVs were also investigated. Pathway enrichment analysis and associations between significant CNVs, clinical parameters, and 5-year progression-free survival were investigated to assess the potential clinical significance of these CNVs.
GCT CNVs from various populations were also compared.the gain of the 7q11.22 region and the loss of the 11p15.5 region are the major characteristics of this GCT cohort. Developmental pathways, DNA damage repair, and SUMOylation may play an essential role in GCT pathogenesis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE348nnn/GSE348707 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE348707 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1535475 ncbi.nlm.nih.gov/bioproject/PRJNA1535475 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Methylation profiling by genome tiling array
- From keywords
- Life Sciences
- Inferred from text
- Germ cell tumor 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE348707 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:germ-cell-tumor | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-genome-tiling-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |