RNA-Seq analysis LPCAT3 knockdown effect on primary human endometrial stromal cells(HESC).

It involves profound cellular and molecular changes, including alterations in energy metabolism, which are necessary to support the increased metabolic demands of the decidualizing cells. The enzyme lysophosphatidylcholine acyltransferase 3 (LPCAT3), known for its role in lipid remodeling, is hypothesized to influence the metabolic shifts occurring during HESC decidualization.

To explore this hypothesis, we employed RNA sequencing (RNA-Seq) to assess the transcriptomic changes in HESCs following LPCAT3 knockdown during the decidualization process.