Omics · study · 2026
Transcriptomic profiling of HaCaT cells after 24-hour exposure to Fusobacterium nucleatum-derived outer membrane vesicles
Listed in NCBI GEO
Fusobacterium nucleatum is an anaerobic Gram-negative bacterium implicated in mucosal inflammatory conditions.
Description
Outer membrane vesicles (OMVs) derived from Gram-negative bacteria are recognized as important mediators of host–microbe interactions. In this study, bulk RNA sequencing was performed to investigate global gene expression changes in HaCaT human keratinocytes following 24-hour treatment with F.n-OMVs (10 μg/mL).
The dataset provides transcriptomic profiles of treated and untreated cells and serves as a resource for exploring host cellular responses to bacterial vesicles.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE320nnn/GSE320506 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320506 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1428736 ncbi.nlm.nih.gov/bioproject/PRJNA1428736 ↗
project · from NCBI GEO
- PubMed 42048970 pubmed.ncbi.nlm.nih.gov/42048970 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE320506 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |