Omics · study · 2026
RNA sequencing analysis of photon irradiated 5-, 7- and 11-day old thyroid gland organoids
Listed in NCBI GEO
The specific effects of radiotherapy treatment on thyroid physiology remain poorly understood.
Description
In our previous work, we characterized thyroid gland organoids grown from isolated mice thyroid cells. Herein, we used this model to investigate the events occurring at 2 days post-irradiation (corresponding to 7-day-old organoids) and at 6 days post-irradiation (corresponding to 11-day-old organoids) using bulk RNA sequencing.
To compare the expression profile to an healthy standard sample, 5-day-old organoids (day of irradiation) were used as controls. This analysis outlined key dysregulated pathways activated in thyroid cells with photon exposure.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303892 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303892 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1298175 ncbi.nlm.nih.gov/bioproject/PRJNA1298175 ↗
project · from NCBI GEO
- PubMed 42380097 pubmed.ncbi.nlm.nih.gov/42380097 ↗
publication · from NCBI GEO
- PubMed 41730478 pubmed.ncbi.nlm.nih.gov/41730478 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Genetics 68% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE303892 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (68%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |