Omics · study · 2026
Identification of a set of transcriptional regulators involved in the temporal regulation of neuron subtype differentiation [RNA-Seq 2]
Listed in NCBI GEO
The sequential generation of various types of neurons and glia from neural stem /progenitor cells (NSPCs) during development is a major part to build complex central nervous system.
Description
Here, we identify PHF21b, ZFP7 and ZFP57 as crucial factors that regulate the transition from early-born neuron to late-born neuron generation by NSPCs in the developing mouse cortex. Simultaneous knockdown of these genes suppressed generation of early-born neurons.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324318 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324318 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1434407 ncbi.nlm.nih.gov/bioproject/PRJNA1434407 ↗
project · from NCBI GEO
- PubMed 42000103 pubmed.ncbi.nlm.nih.gov/42000103 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Genetics 70% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE324318 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (70%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |