Omics · study · 2026
Gallic acid chemoprevention of oral carcinogenesis
Listed in NCBI GEO
Naturally derived phytochemicals such as gallic acid (GA) exhibit multitargeted anticancer properties and favorable safety profiles, yet the molecular mechanisms underlying their chemopreventive effects in head and neck squamous cell carcinoma (HNSCC) remain incompletely defined.
Description
Using a 4 nitroquinoline 1 oxide (4NQO) induced oral carcinogenesis mouse model, we evaluated GA’s effects on tumor progression, and related molecular pathways.
Phenotypic outcomes were assessed by histopathology, and proliferation markers. Transcriptomic changes were profiled by RNA sequencing, pathway enrichment and validation using RT qPCR. We report GA as a key modulator of transcriptional programs associated with oral carcinogenesis in a 4-nitroquinoline-1-oxide–induced mouse model.
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Comparative RNA sequencing of wild-type vehicle-treated (WtVeh) and GA-treated (WtGal) oral tissues revealed GA-dependent reprogramming of immune and stress-response pathways. Our data identifies unique molecular pathways associated with GA mediated oral cancer chemoprevention.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318223 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318223 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1416937 ncbi.nlm.nih.gov/bioproject/PRJNA1416937 ↗
project · from NCBI GEO
- PubMed 42045397 pubmed.ncbi.nlm.nih.gov/42045397 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE318223 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |