Data · study · 2026
Tlr4 Epidermal Genetic Deletion Protects Against Acute and Tumorigenic UV Exposure in SKH-1 Mouse Skin
Listed in NCBI GEO
Solar ultraviolet (UV) exposure activates Toll-Like Receptor 4 (TLR4), initiating inflammatory signaling pathways relevant to human skin carcinogenesis.
Description
Using transcriptomic (Nanostring-based) and proteomic (reverse phase protein array-based) analysis we demonstrate that genetic deletion of epidermal Tlr4 mimics the photoprotective impact of pharmacological antagonism using topical resatorvid (RES), an effect not observed in transgenic mice harboring systemic deletion of Tlr4.
These findings suggest that epidermal TLR4 represents a promising target for skin cancer photochemoprevention.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346544 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346544 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1525733 ncbi.nlm.nih.gov/bioproject/PRJNA1525733 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE346544 | 7 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |