Omics · study · 2026
Transcriptomic analysis of KLRG1+CD127- CD8 T cells in the liver following treatment with anti-CD137 agonistic antibody
Listed in NCBI GEO
We have employed bulk RNA sequencing approach to study cells associated with hepatotoxicity caused by treatment with anti-CD137 agonistic antibody.
Description
We found that the treatment-induced CD11c+KLRG1+ and CD11c-KLRG1+ CD8 T cells were main producers of IFNγ in the liver, suggesting their pathogenic role in the hepatotoxicity. Transcriptomic analysis revealed differential gene expression of inhibitory receptor NKG2A, activating receptor NKG2D, granzyme A, and adhesion molecule Ly6C in the CD11c+ population.
This study represents the analysis of CD11c+ and CD11c- populations of KLRG1+CD127- CD8 T cells in the liver following anti-CD137 agonistic antibody treatment.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300148 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300148 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1279126 ncbi.nlm.nih.gov/bioproject/PRJNA1279126 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE300148 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |