Targeted therapy for triple-negative breast cancer via a membraneencased multi-active iron-sulfur nanoinducer

Accumulating studies have revealed its susceptibility to ferroptosis, rendering ferroptosis inducers highly promising for the treatment of this cancer. This study aimed to evaluate the effect of a membrane-encased iron-sulfur nanoinducer (ISN) for the targeted treatment of TNBC.

The ISN was developed with unique features combining enzyme-like activities and iron-releasing capabilities, functioning synergistically as a potent ferroptosis inducer. It exhibited dual enzymatic activities that synergistically promoted tumor cell death. The peroxidase-like activity of the ISN intensified oxidative stress in tumor cells, while its glutathione oxidase-like activity suppressed glutathione peroxidase 4 expression and depleted glutathione.