Omics · study · 2026
Blood Flow-Mediated Biomechanical Activation of Yap/Taz-Driven Transcriptional Regulation of Self-renewal Programs Controls Developmental Hematopoietic Stem Cell Expansion
Listed in NCBI GEO
Mechanical forces from blood flow are essential for production of hematopoietic stem and progenitor cells (HSPCs) during embryogenesis, but the molecular mechanisms by which hemodynamic cues are sensed and orchestrate endothelial-to-hematopoietic (EHT) transition remain incompletely defined.
Description
In this study, we employed 10x Genomics scRNAseq to characterize the transcriptomic changes in Kdrl+ hematovascular cells in which the mechanoresponsive transcription factors (TF) YAP and TAZ were perturbed by gain- and loss-of-function (GOF/LOF) approaches to understand how these TFs regulate EHT.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335024 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335024 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1477118 ncbi.nlm.nih.gov/bioproject/PRJNA1477118 ↗
project · from NCBI GEO
- PubMed 42490769 pubmed.ncbi.nlm.nih.gov/42490769 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Danio rerio · Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE335024 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:7955 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |