Supplementary file 1_Pediatric lymphomatoid papulosis: a broad clinicopathologic spectrum including rare variants in a single-center case series.docx

Despite its indolent course, LyP may mimic malignant lymphomas clinically and histopathologically, making diagnosis challenging in pediatric patients.</p>Objectives<p>To characterize the clinical, histopathologic, immunophenotypic and molecular features of pediatric LyP and to describe treatment approaches and clinical outcomes.</p>Methods<p>We performed a retrospective observational study of pediatric patients with clinicopathologically confirmed LyP evaluated at our tertiary referral center between 2004 and 2025.

Demographic, clinical, histopathologic, immunophenotypic, molecular, treatment and follow-up data were collected.</p>Results<p>Nine patients were included (8 males, 1 female), with a median age at diagnosis of 11 years (range 2–18). Lesions predominantly involved the limbs (9/9, 100%), followed by the trunk (5/9, 56%) and hands (4/9, 44%). Ulceration or necrotic evolution occurred in 6/9 patients (67%).