Omics · study · 2026
GLI2 mediates response to paclitaxel in triple-negative breast cancer
Listed in NCBI GEO
Bone is the most frequent site of both metastasis and recurrence for patients with breast cancer, and there are currently no FDA-approved therapeutics which target cancer in bone.
Description
Skeletal metastases upregulate the transcription factor Glioma-associated oncogene 2 (Gli2), resulting in secretion of parathyroid hormone-related protein (PTHrP), which accelerates bone turnover and enables tumor proliferation. Gli2 has been implicated as a mediator of chemoresistance in a wide range of cancers, but its unique role in drug resistance has yet to be defined in treatment-resistant skeletal metastases.
Therefore, this dataset aims to define the impact of GLI2 CRISPR knockout on transcriptional response to paclitaxel (PTX), the current standard of care for breast cancer patients with distant metastases.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE302nnn/GSE302168 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE302168 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1289134 ncbi.nlm.nih.gov/bioproject/PRJNA1289134 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE302168 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |