Supplementary file 1_Risk factors associated with prolonged stay in the post-anesthesia care unit: a case-control study.docx

This study aims to identify additional factors associated with prolonged PACU stay and to develop a nomogram for individualized risk assessment.</p>Methods<p>This retrospective study included 69,123 adult patients who were transferred to PACU after general anesthesia from January 2022 to January 2024.

PLOS was defined as PACU stay > 2 hours; non-PLOS controls were matched 3:1 by operative date (±1 month), age (±1 year), and gender. A predictive model was developed using LASSO regression for variable selection and multivariable conditional logistic regression, then presented as a nomogram.</p>Results<p>Among 68,178 eligible patients, 210 subjects were identified as PLOS in PACU. Multivariable conditional logistic regression showed that the potential risk factors were emergency surgery (OR 7.678, 95% CI 2.606-22.618, P < 0.001), increased intraoperative blood loss (OR 1.002, 95% CI 1.001-1.004, P = 0.005), longer operative time (OR 1.004, 95% CI 1.001-1.008, P = 0.011), cerebrovascular diseases (OR 2.248, 95% CI 1.162-4.346, P = 0.016) and major surgery (OR 4.954, 95% CI 1.801-13.624, P = 0.002).