Imaging · study · 2026
Overactivation of SHH signaling during embryonic choroid plexus development induces a cascade of dedifferentiation and carcinoma formation.
Listed in NCBI GEO
Choroid Plexus Carcinomas are highly malignant tumors arising predominantly in very young children and are associated with poor survival.
Description
Details on tumor initiation as well as oncogenic events are largely unknown. We generated hGFAP-cre::lsl-MYCN::lsl-Gli2(N)::Tp5fl/fl mice which developed tumors by the transition from multiciliated, differentiated cells towards monociliated highly proliferating cells.
We profiled these tumors using spatial transcriptomics and revealed details of the dedifferntiation cascade that leads to tumor formation, the relevance of SHH signaling and identified druggable targets for future therapies.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE289nnn/GSE289052 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE289052 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1220711 ncbi.nlm.nih.gov/bioproject/PRJNA1220711 ↗
project · from NCBI GEO
- PubMed 42629571 pubmed.ncbi.nlm.nih.gov/42629571 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Mus musculus · Other
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE289052 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |