Omics · study · 2026
Transcriptomic profiling of cells treated with a novel CDK12/13 inhibitor, CTX-439
Listed in NCBI GEO
We developed a novel clinical-grade CDK12/13 inhibitor, CTX-439, and analyzed transcriptomic changes upon CTX-439 treatment.
Description
CTX-439 downregulated a large number of genes including DDR genes. By analyzing rRNA-depleted nuclear RNA, CTX-439 caused a defect in 3' end processing, showing an increased readthrough transcription.
This caused rapid MCL1 downregulation, which can be combined with BCL-xL inhibition to induce apoptosis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE291nnn/GSE291144 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE291144 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1232092 ncbi.nlm.nih.gov/bioproject/PRJNA1232092 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE291144 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |