Omics · study · 2026
Early transcriptional responses of mouse bone marrow-derived macrophages to Mycobacterium wolinskyi QL01
Listed in NCBI GEO
Mycobacterium wolinskyi is an emerging rapidly growing nontuberculous mycobacterium, but the early host response to this species remains poorly characterized.
Description
To investigate the macrophage response to M. wolinskyi, primary bone marrow-derived macrophages from C57BL/6J mice were infected with the clinical isolate QL01; matched uninfected macrophages served as controls. Poly(A)-selected RNA sequencing was performed with three biological replicates per group.
Transcriptomic analysis revealed extensive differential gene expression and positive enrichment of TNF, NF-kappa B, C-type lectin receptor, and Toll-like receptor signaling pathways in QL01-infected macrophages. These data characterize the early innate immune and pro-inflammatory transcriptional response of macrophages to M. wolinskyi QL01.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344892 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344892 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1517702 ncbi.nlm.nih.gov/bioproject/PRJNA1517702 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE344892 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |