Omics · study · 2026
Bulk RNA-seq of EO771 tumor sample Gq_DREADD vs. Ctr
Listed in NCBI GEO
Bulk RNA-seq was performed to compare mRNA expression in EO771 murine breast tumors between tumors expressing a Gq-DREADD driven CRH-neuron activation paradigm (DCZ injection at in-phase ZT10.5) and matched controls receiving PBS.
Description
The goal is to identify transcriptional programs in the tumor that are altered downstream of CRH-neuron activation (acute transcriptional responses, immune/tumor cell signaling, and pathway changes) and generate data suitable for differential expression, pathway enrichment, and hypothesis generation for follow-up functional work.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309464 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309464 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1336125 ncbi.nlm.nih.gov/bioproject/PRJNA1336125 ↗
project · from NCBI GEO
- PubMed 41401811 pubmed.ncbi.nlm.nih.gov/41401811 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE309464 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |