Omics · study · 2026
RNA-seq analysis of FACS-sorted pre-metastatic lung endothelial cells reveal transcriptional programs regulated by cisplatin and FAK in the pre-metastatic lung
Listed in NCBI GEO
This study investigates the mechanisms underlying DNA-damage driven vascular endothelial-cell senescence regulated by EC-FAK and its role in lung cancer metastasis.
Description
RNA-seq analysis has been performed FACS-sorted pre-metastatic lung endothelial cells to identify FAK-regulated transcriptomic changes due to DNA- damaging therapy in tumour burdened and non-tumour burdened mice (comparisons between Cre-negative ECFAK WT mice with Cre-positive ECFAK KO mice in Cisplatin treated samples.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328693 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328693 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1456142 ncbi.nlm.nih.gov/bioproject/PRJNA1456142 ↗
project · from NCBI GEO
- PubMed 42687863 pubmed.ncbi.nlm.nih.gov/42687863 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 68% · Cancer 75% · RNA sequencing 65%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE328693 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (68%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |