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Omics · study · 2026

CD40ag Activated B Cells Elicit Anti-Tumor Immunity [scRNAseq]

Listed in NCBI GEO

We leveraged mouse models of Triple Negative Breast cancer of varying tumor mutation burdens to elucidate ways that direct activation of B cells can illiciate an anti-tumor effect.

Description

These syngenic tranplant models were treated with a combination of CD40 agonist immunotherapy or anti-CD19. Primary tumors of both treated and nontreated conditions were profiled by RNA-SEQ.

These tumors that have been profiled describe the impact that B cell acitvation has on CD40 agonist immunotherapy treatment and tumor progression.

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Stated by source
Expression profiling by high throughput sequencing · Mus musculus
From keywords
Life Sciences
Inferred from text
Cancer 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE27600614 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[disease].local:disease:cancerenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (65%)
concepts[organism].NCBITaxon:10090source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title