Omics · study · 2026
Transcriptomic response to corticosterone treatment in murine osteoblasts.
Listed in NCBI GEO
To assess the transcriptomic response to corticosterone treatment in osteoblasts, we treated differentiated MC3T3 osteoblasts cells with 100 nM corticosterone for 24 hours.
Description
Comprehensive RNA-seq analysis was performed to identify differentially expressed genes and pathways associated with glucocorticoid receptor activation, osteoblast activity, and inflammatory responses. This study provides insights into the molecular mechanisms underlying corticosterone-mediated suppression of FGF23 expression and its broader effects on bone metabolism.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304562 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304562 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1301791 ncbi.nlm.nih.gov/bioproject/PRJNA1301791 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE304562 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |