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Table · dataset · 2026

Supporting data for "THE ROLE OF PURMORPHAMINE IN ENHANCING SECRETIN MEDIATED SYSTEMIC METABOLIC HOMEOSTASIS"

Listed in figshare and Loughborough Research Repository — shown once because both records carry DOI 10.25442/hku.33368983.v1

<p dir="ltr">This dataset contains the primary laboratory research data supporting the thesis titled 'THE ROLE OF PURMORPHAMINE IN ENHANCING SECRETIN MEDIATED SYSTEMIC METABOLIC HOMEOSTASIS'.

Description

The research investigates the therapeutic potential of purmorphamine (Pur) as a positive allosteric modulator of the secretin receptor (SCTR) in addressing obesity-associated metabolic dysfunctions. The dataset encompasses both <i>in vivo</i> physiological phenotyping and <i>in vitro</i> cellular and molecular assays.

Specifically, it includes comprehensive metabolic monitoring records—such as real-time energy expenditure, indirect calorimetry, infrared thermography, and glucose/insulin tolerance test results—collected from diet-induced obese (DIO) mice. Furthermore, it contains cellular bioenergetics data (e.g., Seahorse oxygen consumption rates), gene expression transcripts (RT-qPCR), protein quantification images (Western Blot), and flow cytometry records derived from brown adipocytes (T37i) and cardiomyocytes (AC16).

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These files collectively demonstrate the mechanisms by which SCTR allosteric modulation coordinates brown adipose tissue thermogenesis and cardiac metabolic flexibility. All data are organized by figure numbers and provided in standardized formats to support reproducibility.</p>

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Where it is published

Catalogue records · 1

Topics

From keywords
Astronomy & Astrophysics · Cell metabolism · Cell metabolism · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Humanities · Humanities · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science
Inferred from text
Heart 65% · Image 65%
Provenance · 2 source records, 32 field assertions
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figshareoai:figshare.com:article/3336898312 d agoJSON v1
Loughborough Research Repositoryoai:figshare.com:article/3336898312 d agoJSON v1
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