Omics · study · 2026
Transcriptomic Analysis of WT and IGF2BP2 KO Macrophages Reveals Metabolic Alterations
Listed in NCBI GEO
This dataset contains RNA-Seq data from wild-type (WT) and IGF2BP2 knockout (KO) bone marrow-derived macrophages (BMMs) under basal and IL-4-stimulated conditions.
Description
Loss of IGF2BP2 led to significant transcriptional changes, particularly in genes regulating metabolism, mitochondrial function, and cell migration. Pathway analysis revealed a metabolic shift toward glycolysis and reduced migratory capacity.
Details: Int J Biol Sci 2026; 22(6):2754-2773. doi:10.7150/ijbs.122142
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE292nnn/GSE292558 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292558 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1238510 ncbi.nlm.nih.gov/bioproject/PRJNA1238510 ↗
project · from NCBI GEO
- PubMed 41943844 pubmed.ncbi.nlm.nih.gov/41943844 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Genetics 70% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE292558 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (70%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |